WCIRDC 2025 Resource Hub  – 

Welcome to our resource hub for WCIRDC 2025! This is a one-stop-shop for all your WCIRDC 2025 needs. We will be updating the resource hub daily, so check back in for the latest on this fantastic meeting.

Day-of Conference Reports

  1. Day #1 Highlights
  2. Day #2 Highlights
  3. Day #3 Highlights
  4. Day #4 Highlights

Top Highlights

  1. Back to basics: Insulin resistance as a foundational defect in T2D pathogenesis
  2. “Pre-prediabetes”: The association between insulin resistance and cardiometabolic risk in people without obesity
  3. Beyond glycemic management: Visceral adiposity as a therapeutic target for HFpEF
  4. Cardiovascular prevention: Dr. Nathan Wong discusses the role of risk scores, coronary calcium and opportunistic testing for cardiometabolic disease
  5. Combination therapies for CKD and T2D: Dr. Jennifer Green spotlights clinical insights from the phase 2 CONFIDENCE trial
  6. Expanding real-world cardiometabolic care: Dr. Pam Taub on the potential of imaging
  7. Dr. Jorge Plutzky explains the role of angiogenesis on cardiometabolic health
  8. Transforming diabetes care through AI‑driven insulin models, decision support, and digital prevention
  9. Mechanistic impacts that may explain how body weight reduction improves metabolic function in the eyes of Dr. Samuel Klein
  10. The role of the duodenum in metabolic dysfunction by Dr. Richard Pratley
  11. Dr. Richard Pratley on Evoke trial results, muscle loss, and geriatric diabetes care
  12. Bayer’s Kerendia (finerenone) improves morbidity and mortality in people with T2D in people with either CKD or HF, irrespective of baseline A1c in a pooled analysis
  13. Liver and obesity: From shared pathogenesis to screening and management by Drs. Jennifer Green, Robert Kushner, and Amreen Dinani
  14. Dr. Brian Feldman explains moving beyond lifestyle interventions to harness thermogenic fat in pediatric obesity
  15. Cortisol: The “forgotten hormone” and the potential underlying factor that impacts insulin resistance
  16. In utero exposure to maternal hyperglycemia and genetic risk independently increase T2D risk in adolescents, according to the HAPO study
  17. Dr. Yehuda Handelsman on hypertension and lipid management
  18. Leptin and endotrophin as dual pillars of fibro-inflammation in cardiometabolic disease
  19. Dr. Ralph DeFronzo on emerging therapies for beta cell regeneration and insulin sensitization
  20. From the eyes of a cardiologist: Perspectives on healthy diets in cardiometabolic health for obesity management
  21. Pipeline updates from Zealand: Advancing amylin innovation and diversifying cardiometabolic therapies
  22. Pipeline updates from Novo Nordisk: Expanding incretin leadership and diversifying into inflammation and beyond
  23. Pipeline updates from AstraZeneca: Addressing root cause of cardiometabolic disease
  24. The role of the liver in the cardiovascular-kidney-metabolic syndrome
  25. Peripheral artery disease in T2D: A modern epidemic of fragmented care
  26. CVOTs in 2025 for heart failure, lipid management, and hypertension
  27. Reframing hypercortisolism in T2D: Insights from the CATALYST trial from Dr. John Buse
  28. Gerald Reaven Award Lecture: Dr. Tracey McLaughlin details pathophysiology behind obesity and metabolic dysfunction
  29. Dr. Sunder Mudaliar explores the “incretin jungle” from GIP paradox to emerging agents
  30. CGM in prediabetes: Sensor variability and the need for new standards
  31. Obesity burden and CGM benefits in people with T1D
  32. Medical management of HFmrEF and HFpEF with rapid sequence or simultaneous initiation of SGLT-2 inhibitors, nsMRAs, and GLP-1 RAs

Previous WCIRDC Coverage on CCKB

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